Digital phenotyping for classification of anxiety severity during COVID-19.

COVID-19 has led to an increase in anxiety among Canadians. Canadian Perspectives Survey Series (CPSS) is a dataset created by Statistics Canada to monitor the effects of COVID-19 among Canadians. Survey data were collected to evaluate health and health-related behaviours. This work evaluates CPSS2 and CPSS4, which were collected in May and July of 2020, respectively. The survey data consist of up to 102 questions. This work proposes the use of the survey data characteristics to identify the level of anxiety within the Canadian population during the first- and second-phases of COVID-19 and is validated by using the General Anxiety Disorder (GAD)-7 questionnaire. Minimum redundancy maximum relevance (mRMR) is applied to select the top features to represent user anxiety, and support vector machine (SVM) is used to classify the separation of anxiety severity. We employ SVM for binary classification with 10-fold cross validation to separate the labels of Minimal and Severe anxiety to achieve an overall accuracy of 94.77 ± 0.13 % and 97.35 ± 0.11 % for CPSS2 and CPSS4, respectively. After analysis, we compared the results of the first and second phases of COVID-19 and determined a subset of the features that could be represented as pseudo passive (PP) data. The accurate classification provides a proxy on the potential onsets of anxiety to provide tailored interventions. Future works can augment the proposed PP data for carrying out a more detailed digital phenotyping.

Digital phenotyping for classification of anxiety severity during COVID-19

COVID-19 has led to an increase in anxiety among Canadians. Canadian Perspectives Survey Series (CPSS) is a dataset created by Statistics Canada to monitor the effects of COVID-19 among Canadians. Survey data were collected to evaluate health and health-related behaviours. This work evaluates CPSS2 and CPSS4, which were collected in May and July of 2020, respectively. The survey data consist of up to 102 questions. This work proposes the use of the survey data characteristics to identify the level of anxiety within the Canadian population during the first- and second-phases of COVID-19 and is validated by using the General Anxiety Disorder (GAD)-7 questionnaire. Minimum redundancy maximum relevance (mRMR) is applied to select the top features to represent user anxiety, and support vector machine (SVM) is used to classify the separation of anxiety severity. We employ SVM for binary classification with 10-fold cross validation to separate the labels of Minimal and Severe anxiety to achieve an overall accuracy of

COVID-19-Associated Encephalopathy (COVEP): Basic Aspects of Neuropathology

SARS-CoV-2, a member of the betacoronavirus group and causative agent of COVID-19, is a virus affecting multiple systems, not only the respiratory. One of the systems affected by the virus is the central nervous system, with neuropathological studies reporting a wide set of morphological phenomena-neuroinflammation, vascular and blood-brain barrier alterations, neurodegeneration, and accelerated aging, while contradicting data is present on the direct neuroinvasive potential of the virus and active viral replication within neurons. The depicted changes, other than an acute effect (which may contribute to the death of the patient) also have chronic sequelae in the context of post-COVID syndrome cognitive impediments, sleep, and mood disorders. The following chapter describe the basic neuropathological aspects of SARS-CoV-2 as based on the present evidence in scientific literature and propose the term COVEP-COVID-associated encephalopathy-to unite the undisputed effects of the infection on nervous system morphology and function.

SARS, MERS and COVID-19-Associated Renal Pathology

Coronaviruses are a large group of RNA viruses, the most notable representatives of which are SARS-CoV, MERS-CoV and SARS-CoV-2. Human coronavirus infections were first documented in the 1960s, when members causing seasonal common colds were successfully replicated in human embryonal trachea and kidney cell cultures and classified based on electron microscopy. The history of coronaviruses stretched far back to that point, however, with some representatives causing disease in animals identified several decades prior and evolutionary data pointing towards the origin of this viral group more than 55 million years ago. In the short time period of research since they were discovered, coronaviruses have shown significant diversity, genetic peculiarities and varying tropism, resulting in the three identified causative agents of severe disease in humans-SARS, MERS and the most recent one, COVID-19, which has surpassed the previous two due to causing a pandemic resulting in significant healthcare, social and political consequences. Coronaviruses are likely to have caused pandemics long before, such as the so-called Asian or Russian influenza. Despite being epitheliotropic viruses and predominantly affecting the respiratory system, these entities affect multiple systems and organs, including the kidneys. In the kidneys, they actively replicate in glomerular podocytes and epithelial cells of the tubules, resulting in acute kidney injury, seen in a significant percentage of severe and fatal cases. Furthermore, the endothelial affinity of the viruses, resulting in endotheliitis, increases the likelihood of thrombotic microangiopathy, damaging the kidneys in a two-hit mechanism. As such, recently, COVAN has been a suggested nomenclature change indicating renal involvement in coronavirus infections and its long-lasting consequences.

SARS-CoV-2 Associated Pulmonary Pathology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel entry in the betacoronaviridae group of coronaviruses. This is the second member of this group, and the third of the family overall to emerge in the last 20 years, which has caused significant health concerns due to the clinical severity and spread of the disease it causes-coronavirus disease identified in 2019 (COVID-19). While initially emerging as a respiratory disease, and while most cases experience symptoms predominantly from this system, SARS-CoV-2 has emerged as a multisystem pathogen. From a pathomorphological point of view, the severity of changes in the respiratory system can be summed up as diffuse alveolar damage-desquamation of the alveolar epithelium with exudative and proliferative changes-pulmonary hyaline membranes, Clara cell hyperplasia, squamous cell metaplasia, and fibrosis. The second most prominent way the disease affects the lung is through endotheliitis-damage to the endothelial cells of the pulmonary vasculature, predominantly affecting the medium and large caliber blood vessels that cause the well-established clinical phenomenon of thrombosis/thromboembolism of the pulmonary vasculature. As the spread of the disease continues with the emergence of new variants and the number of cases continues to grow, including a large percentage of recurrent cases, it is essential to remember that the viral effects are not only acute but, due to the proliferative phenomena, can produce chronic sequelae. Therefore, in the background of dwindling publication interest, it is critical to focus on the histopathological aspects of the pulmonary disease, with the goal of better understanding the effects of the virus on the organism and identifying probable future complications after infection.